Poster Presenter: Michelle Barraclough, PhD, Research Fellow, University Health Network, Toronto, Canada
Poster Title: Evolution of Subjective Cognitive Impairment Over Time in SLE Patients: Bayesian Longitudinal Item Response Theory Modelling
Ignite Session 3C
Sunday, November 13 | 9:30–9:35 a.m. ET | South Philly Stage
All ACR Convergence 2022 poster presentations are available on demand to registered meeting participants through October 31, 2023.
What is your poster about?
Subjective cognitive impairment (SCI) in systemic lupus erythematosus (SLE) is a significant problem that affects quality of life. Using the Perceived Deficits Questionnaire (PDQ-20), we investigated how SCI changes over time. As this questionnaire is a Likert scale, and we wanted to look at longitudinal data, which required a novel statistical approach, we used Bayesian longitudinal item response theory modeling. The results suggested that SCI may worsen over time.
Why did you decide to investigate this topic?
Cognitive impairment is a complex condition in SLE. There are many factors that can affect it and many ways to measure it. As part of larger studies, we are investigating these aspects. For this particular analysis, we wanted to understand the trajectory of SCI in SLE. This will be used in future analysis.
What are you working on next related to this research?
We plan to use this novel analysis to test for different trajectories, for example, do all SLE patients with SCI get worse over time, or do some get better or stay the same? We will then examine which patient characteristics drive these changes in SCI. Ultimately, this information can be used to better treat this condition.
What excites you most about your work?
Cognitive impairment, especially subjective/self-reported impairment, has limited treatment options available for SLE patients. By continuing to examine this field, we are hopefully getting one step closer to finding better treatment options for this condition.
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