ABSTRACT: Opposing Pathogenic Roles of Endothelial and Fibroblast Insulin-Like Growth Factor Binding Protein-7 (IGFBP7) in Systemic Sclerosis-Associated Pulmonary Hypertension (SSc-PH)

Abstract Presenter: Gayathri Guru Murthy, MS, PhD Candidate, University of Rochester

Gayathri Guru Murthy, MS, PhD
Gayathri Guru Murthy, MS

Abstract Title: Opposing Pathogenic Roles of Endothelial and Fibroblast Insulin-Like Growth Factor Binding Protein-7 (IGFBP7) in Systemic Sclerosis-Associated Pulmonary Hypertension (SSc-PH)

Abstract Session: Abstracts: Systemic Sclerosis & Related Disorders – Basic and Translational Science (1934-1939), 3–4:30 p.m. Monday, November 9

What is your abstract about? 

Murthy: My poster and research explore the biological function and mechanism of IGFBP7 in systemic sclerosis-associated pulmonary hypertension (SSc-PH). This work will advance our understanding of SSc-PH and, hopefully, identify a therapeutic/drug target for SSc-PH. 

Why did you decide to investigate this topic?

Murthy: My family has a history of autoimmune diseases, especially in most women who raised me, so when I got the chance to study systemic sclerosis (SSc), also an autoimmune disease affecting women, I saw it as a chance to contribute to women’s health research. It also helps that immunology has been my favorite subject since undergrad.

Studying IGFBP7 in SSc-PH gives us a chance to find a cure for this rare but high-mortality disease. 

What are you working on next related to this research?

Murthy: Identifying more mechanisms and interactions of IGFBP7 in scleroderma and SSc-PH. 

What excites you most about your work?

Murthy: I get to collaborate with many scientists to study different aspects of SSc. One of the main techniques I use is immunofluorescent microscopy, and every time I image a tissue as part of my experiments, it is as exciting and enthralling as the first time.

What are you most looking forward to at ACR Convergence 2026 in Orlando?

Murthy: Reconnecting with the ACR community and catching up with old friends and new. It is like homecoming.